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Role of lubricin and boundary lubrication in the

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Lubricin: New Promise for Joint-Preserving Therapy .

The boundary mode of the synovial joint is lubricated during periods of low sliding speed (less than 0.3 mm/sec) 1 and high physiologic loads (approaching 5 mPa) 2 by hyaluronic acid and lubricin, which prevents the pressurized joint surfaces from adhering to each other. 3 Boundary lubricants comprise a layer that is less than the height of the asperities (roughness) of the joint surfaces. 4,7,8

Boundary mode lubrication of articular cartilage by .

Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant. It is unclear how lubricin boundary lubricates a wide range of bearings from tissue to artificial surfaces, and if the mechanism is the same for both soluble and bound lubricin.

PNAS揭示关节炎防治新方法 - 生物

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Osteoarthritis is a complex disease involving the mechanical breakdown of articular ...

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Role of lubricin and boundary lubrication in the .

Title: Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis: Authors: Waller, K. A.; Zhang, L. X.; Elsaid, K. A.; Fleming, B. C ...

The biology of Lubricin: Near frictionless joint motion .

Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.

Biotribological Assessment for Artificial Synovial Joints .

Biotribological Assessment for Artificial Synovial Joints: The Role of Boundary Lubrication Doctorate of Philosophy in Biomedical Engineering by LORNE R GALE, BE(Mech, Hons) Thesis submitted for the degree of Doctor of Philosophy, School of Engineering Systems, Institute of Health and Biomedical Innovation (IHBI),

Lubricants | Free Full-Text | Experimental Investigations .

The major role of lubricin in boundary lubrication is nowadays well-accepted . However, the experimental observation of the hydrophobicity of the articular cartilage contradicts a scheme where a glycosylated and, therefore, hydrophilic protein such as lubricin would be the main boundary lubricant. ...

2. Definition, Function, and Structure of Lubricin and Its .

The boundary lubrication of the surfaces has also been studied, and the role of lubricin and HA (polyelectrolyte) during the initiation and progression and later stages of wear has been investigated in their experiments.

Transcription, Translation, and Function of Lubricin, a .

Lubricin plays a critical role as a boundary lubricant in articulating joints. 1-4 This amphiphilic glycoprotein, which is also called superficial zone protein, ... Boundary lubrication may also be dominant at the cornea–contact lens interface where there is a relative lack of aqueous tear.

Regulation of lubricin for functional cartilage tissue .

Structure and functional role of lubricin. Lubricin, a product of the proteoglycan 4 (PRG4) gene, is highly expressed by synoviocytes and superficial zone chondrocytes [].Lubricin, generally known as a proteoglycan, is a glycoprotein that functions as a critical boundary lubricant for articular cartilage and normally isolated from synovial fluid [].

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptos

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis Kimberly A. Wallera, Ling X. Zhangb, Khaled A. Elsaidc, Braden C. Fleminga,d,e, Matthew L. Warmanf,g, and Gregory D. Jaya,b,h,1 aCenter for Biomedical Engineering and the School of Engineering, Brown University, Providence, RI 02912; bEmergency Medicine Research Laboratory, Department of Emergency Medicine ...

Friction force microscopy of lubricin and hyaluronic acid .

Lubricin and hyaluronic acid (HA) are two constituents of synovial fluid thought to have a role in boundary lubrication. Boundary lubrication3 is accomplished by lubricants adsorbed or bonded to the apposing bearing surfaces and is operative where surfaces come into contact.4 It is one of the multiple

The role of lubricin in the ... - PubMed Central (PM

Therefore, lubricin provides a chondroprotective feature to synovial fluid that is distinct from the role lubricin plays at the cartilage surface as a boundary lubricant. Additional MPTM experiments, which involve reintroducing lubricin to HA in the presence of the synovial protein milieu, are needed.

Role of lubricin and boundary lubrication in the .

Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death, but the connection between these factors is not well established. Lubricin, a mucinous glycoprotein encoded by the PRG4 gene, provides boundary lubrication in articular joints. Joint friction is elevated and accompanied by accelerated ...

Proteoglycan 4 - Wikiped

Function. Lubricin is present in synovial fluid and on the surface (superficial layer) of articular cartilage and therefore plays an important role in joint lubrication and synovial homeostasis.When first isolated, cartilage lubricin was called "superficial zone protein" (SZP). Lubricin, MSF, and SZP are now collectively known as Proteoglycan 4 (hence PRG4 for the gene nomenclature).

The role of lubricin in the mechanical behavior of .

Request PDF on ResearchGate | The role of lubricin in the mechanical behavior of synovial fluid | Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on ...

The role of lubricin in normal and pathological joint tissue: a contemporary revi

The aim of this article was to critically review the literature about lubricin and its involvement in normal and pathological joint tissue. In particular, our research focussed on new therapeutic approaches for the treatment of osteoarthritis related to lubricin. We reviewed the literature regarding lubricin expression.