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CA2654019A1 Hepatocyte growth factor hgf binding

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Direct binding of hepatocyte growth factor and vascular .

In order to understand the role of CD44v6 in Met and VEGFR-2 activation and signalling we tested whether CD44v6 binds to their ligands, HGF (hepatocyte growth factor) and VEGF (vascular endothelial growth factor), respectively. FACS analysis and cellular ELISA showed binding of HGF and VEGF only to cells expressing CD44v6.

CA2654019A1 - Hepatocyte growth factor (hgf) binding .

The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF. responsive disorders, for example, certain HGF responsive tumors.

US7659378B2 - Hepatocyte growth factor (HGF) binding .

The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

Detection of Hepatocyte Growth Factor (HGF) Ligand-c-MET .

Hepatocyte growth factor (HGF; also known as scatter factor) is the only known c-MET ligand . Binding of HGF to c-MET triggers c-MET receptor activation via autophosphorylation of the cytoplasmic domain and recruitment of adaptor proteins that potentiates cell signaling .

CA2654019A1 - Hepatocyte growth factor (hgf) binding .

The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF. responsive disorders, for example, certain HGF responsive tumors.

HGF - Anti-HGF Antibodies, shRNA, siRNA & Gene Information .

Human(3082) Summary: Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin.

CA2654019A1 - Hepatocyte growth factor (hgf) binding .

The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF. responsive disorders, for example, certain HGF responsive tumors.

Hepatocyte Growth Factor/c-Met Signaling in Head and Neck .

Targeted Inhibition of Hepatocyte Growth Factor (HGF)/c-Met Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC). Secreted by local tumor associated ļ¬broblasts (TAFs), pro-HGF is cleaved by membrane bound matriptase, enabling the heterodimer ligand to bind both the alpha and beta chain of the c-Met receptor.

Macrocyclic peptide-based inhibition and imaging of .

Activation of hepatocyte growth factor (HGF) by proteolytic processing is triggered in cancer microenvironments, and subsequent signaling through the MET receptor is involved in cancer progression.

Hepatocyte growth factor/scatter factor binds with high .

We have demonstrated by affinity chromatography that hepatocyte growth factor/scatter factor (HGF/SF) binds strongly to dermatan sulfate (DS), with a similar ionic strength dependence to that previously seen with heparan sulfate (HS). Analysis of binding kinetics on a biosensor yields an equilibrium dissociation constant, K(D), of 19.7 nM.

CA2654019A1 - Hepatocyte growth factor (hgf) binding .

The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF. responsive disorders, for example, certain HGF responsive tumors.

Heparin Binding and Oligomerization of Hepatocyte Growth Factor/Scatter Factor Isoforms HEPARAN SULFATE GLYCOSAMINOGLYCAN REQUIREMENT FOR Met BINDING AND SIGNALI

Abstract. Hepatocyte growth factor/scatter factor (HGF/SF) is a heparin-binding polypeptide that stimulates cell proliferation, motility, and morphogenesis by activation of its receptor, the c-Met tyrosine kinase.

CA2654025A1 - Hepatocyte growth factor (hgf) binding .

The present application provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

US7659378B2 - Hepatocyte growth factor (HGF) binding .

The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

CA2804399A1 - Anticorps anti-ron - Google Paten

CA2804399A1 CA 2804399 CA2804399A CA2804399A1 CA 2804399 A1 CA2804399 A1 CA 2804399A1 CA 2804399 CA2804399 CA 2804399 CA 2804399 A CA2804399 A CA 2804399A CA 2804399 A1 CA2804399 A1 CA 2804399A1 Authority CA Canada Prior art keywords seq id amino acid acid sequence variable region chain variable Prior art date 2010-07-06 Legal status (The legal status is an assumption and is not a legal ...

US7659378B2 - Hepatocyte growth factor (HGF) binding .

The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

Hepatocyte growth factor - Wikiped

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic ...

CA2804399A1 - Anticorps anti-ron - Google Paten

CA2804399A1 CA 2804399 CA2804399A CA2804399A1 CA 2804399 A1 CA2804399 A1 CA 2804399A1 CA 2804399 CA2804399 CA 2804399 CA 2804399 A CA2804399 A CA 2804399A CA 2804399 A1 CA2804399 A1 CA 2804399A1 Authority CA Canada Prior art keywords seq id amino acid acid sequence variable region chain variable Prior art date 2010-07-06 Legal status (The legal status is an assumption and is not a legal ...

CA2804399A1 - Anticorps anti-ron - Google Paten

CA2804399A1 CA 2804399 CA2804399A CA2804399A1 CA 2804399 A1 CA2804399 A1 CA 2804399A1 CA 2804399 CA2804399 CA 2804399 CA 2804399 A CA2804399 A CA 2804399A CA 2804399 A1 CA2804399 A1 CA 2804399A1 Authority CA Canada Prior art keywords seq id amino acid acid sequence variable region chain variable Prior art date 2010-07-06 Legal status (The legal status is an assumption and is not a legal ...